9,391 research outputs found
LLV - Lunar Logistic Vehicle Final report
Evaluation of systems design training institute for engineering facult
Theory of ac electrokinetic behavior of spheroidal cell suspensions with an intrinsic dispersion
The dielectric dispersion, dielectrophoretic (DEP) and electrorotational (ER)
spectra of spheroidal biological cell suspensions with an intrinsic dispersion
in the constituent dielectric constants are investigated. By means of the
spectral representation method, we express analytically the characteristic
frequencies and dispersion strengths both for the effective dielectric constant
and the Clausius-Mossotti factor (CMF). We identify four and six characteristic
frequencies for the effective dielectric spectra and CMF respectively, all of
them being dependent on the depolarization factor (or the cell shape). The
analytical results allow us to examine the effects of the cell shape, the
dispersion strength and the intrinsic frequency on the dielectric dispersion,
DEP and ER spectra. Furthermore, we include the local-field effects due to the
mutual interactions between cells in a dense suspension, and study the
dependence of co-field or anti-field dispersion peaks on the volume fractions.Comment: accepted by Phys. Rev.
Human Heme Oxygenase Oxidation of 5- and 15-Phenylhemes
Human heme oxygenase-1 (hHO-1) catalyzes the O2- dependent oxidation of heme to biliverdin, CO, and free iron. Previous work indicated that electrophilic addition of the terminal oxygen of the ferric hydroperoxo complex to the -meso-carbon gives 5-hydroxyheme. Earlier efforts to block this reaction with a 5-methyl substituent failed, as the reaction still gave biliverdin IX . Surprisingly, a 15-methyl substituent caused exclusive cleavage at the -meso- rather than at the normal, unsubstituted -meso-carbon. No CO was formed in these reactions, but the fragment cleaved from the porphyrin eluded identification. We report here that hHO-1 cleaves 5-phenylheme to biliverdin IX and oxidizes 15- phenylheme at the -meso position to give 10-phenylbiliverdin IX . The fragment extruded in the oxidation of 5-phenylheme is benzoic acid, one oxygen of which comes from O2 and the other from water. The 2.29- and 2.11-Ă… crystal structures of the hHO-1 complexes with 1- and 15-phenylheme, respectively, show clear electron density for both the 5- and 15-phenyl rings in both molecules of the asymmetric unit. The overall structure of 15-phenylheme-hHO-1 is similar to that of heme-hHO-1 except for small changes in distal residues 141–150 and in the proximal Lys18 and Lys22. In the 5-phenylhemehHO-1 structure, the phenyl-substituted heme occupies the same position as heme in the heme-HO-1 complex but the 5-phenyl substituent disrupts the rigid hydrophobic wall of residues Met34, Phe214, and residues 26–42 near the -meso carbon. The results provide independent support for an electrophilic oxidation mechanism and support a role for stereochemical control of the reaction regiospecificity.Fil: Wang, Jingling. University of California; Estados UnidosFil: Niemevz, Fernando. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Departamento de QuĂmica Orgánica; ArgentinaFil: Lad, Latesh. University of California; Estados UnidosFil: Huang, Liusheng. University of California; Estados UnidosFil: Alvarez, Diego Ezequiel. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Departamento de QuĂmica Orgánica; ArgentinaFil: Buldain, Graciela Yolanda. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Departamento de QuĂmica Orgánica; ArgentinaFil: Poulos, Thomas L.. University of California; Estados UnidosFil: Ortiz de Montellano, Paul R.. University of California; Estados Unido
Generalized Pseudopotentials for Higher Partial Wave Scattering
We derive a generalized zero-range pseudopotential applicable to all partial
wave solutions to the Schroedinger equation based on a delta-shell potential in
the limit that the shell radius approaches zero. This properly models all
higher order multipole moments not accounted for with a monopolar delta
function at the origin, as used in the familiar Fermi pseudopotential for
s-wave scattering. By making the strength of the potential energy dependent, we
derive self-consistent solutions for the entire energy spectrum of the
realistic potential. We apply this to study two particles in an isotropic
harmonic trap, interacting through a central potential, and derive analytic
expressions for the energy eigenstates and eigenvalues.Comment: RevTeX 4 pages, 1 figure, final published versio
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